CRISPR Cas9-mediated ablation of pyruvate carboxylase gene in colon cancer cell line HT-29 inhibits growth and migration, induces apoptosis and increases sensitivity to 5-fluorouracil and glutaminase inhibitor

Pyruvate carboxylase (PC) is an important anaplerotic enzyme that replenishes the tricarboxylic acid cycle (TCA) intermediates. It prevents the collapse of the TCA cycle upon its intermediates are removed during high anabolic demand. We have recently shown that overexpression of PC protein was assoc...

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Principais autores:	Jarunya Ngamkham, Siraprapa Siritutsoontorn, Saowaluk Saisomboon, Kulthida Vaeteewoottacharn, Sarawut Jitrapakdee
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-11-01
Colecção:	Frontiers in Oncology
Assuntos:	pyruvate carboxylase cancer metabolism colorectal cancer 5-FU glutaminase
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fonc.2022.966089/full
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