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A method for measuring mitochondrial DNA copy number in pediatric populations

The mitochondrion is a multifunctional organelle that modulates multiple systems critical for homeostasis during pathophysiological stress. Variation in mitochondrial DNA (mtDNA) copy number (mtDNAcn), a key mitochondrial change associated with chronic stress, is an emerging biomarker for disease pa...

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Autori principali: Simran Maggo, Liam Y. North, Aime Ozuna, Dejerianne Ostrow, Yander R. Grajeda, Hesamedin Hakimjavadi, Jennifer A. Cotter, Alexander R. Judkins, Pat Levitt, Xiaowu Gai
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2024-06-01
Serie:Frontiers in Pediatrics
Soggetti:
mitochondrial DNA copy number
adversity
lpWGS
adverse childhood experience (ACE)
DNA RNA extraction
Accesso online:https://www.frontiersin.org/articles/10.3389/fped.2024.1401737/full
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