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Melatonin Alleviates Hypoxia-Induced Apoptosis of Granulosa Cells by Reducing ROS and Activating MTNR1B–PKA–Caspase8/9 Pathway

In mammalian ovaries, the avascular environment within follicular cavity is supposed to cause hypoxic status in granulosa cells (GCs), leading to apoptotic cell death accompanied by cumulative reactive oxygen species (ROS) production. Melatonin (N-acetyl-5-methoxytryptamine, MT), a broad-spectrum an...

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Principais autores: Jing-Li Tao, Xuan Zhang, Jia-Qi Zhou, Cheng-Yu Li, Ming-Hui Yang, Zhao-Jun Liu, Liang-Liang Zhang, Shou-Long Deng, Lu Zhang, Ming Shen, Guo-Shi Liu, Hong-Lin Liu
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2021-01-01
Serier:Antioxidants
Fag:
melatonin
hypoxia
granulosa cells
apoptosis
reactive oxygen species
Online adgang:https://www.mdpi.com/2076-3921/10/2/184
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