Melatonin Alleviates Hypoxia-Induced Apoptosis of Granulosa Cells by Reducing ROS and Activating MTNR1B–PKA–Caspase8/9 Pathway

In mammalian ovaries, the avascular environment within follicular cavity is supposed to cause hypoxic status in granulosa cells (GCs), leading to apoptotic cell death accompanied by cumulative reactive oxygen species (ROS) production. Melatonin (N-acetyl-5-methoxytryptamine, MT), a broad-spectrum an...

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Ngā taipitopito rārangi puna kōrero

Ngā kaituhi matua:	Jing-Li Tao, Xuan Zhang, Jia-Qi Zhou, Cheng-Yu Li, Ming-Hui Yang, Zhao-Jun Liu, Liang-Liang Zhang, Shou-Long Deng, Lu Zhang, Ming Shen, Guo-Shi Liu, Hong-Lin Liu
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	MDPI AG 2021-01-01
Rangatū:	Antioxidants
Ngā marau:	melatonin hypoxia granulosa cells apoptosis reactive oxygen species
Urunga tuihono:	https://www.mdpi.com/2076-3921/10/2/184
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!