Intranasal Delivery of Granisetron to the Brain via Nanostructured Cubosomes-Based In Situ Gel for Improved Management of Chemotherapy-Induced Emesis

This research aimed to boost granisetron (GS) delivery to the brain via the intranasal route to better manage chemotherapy-induced emesis. Glycerol monooleate (GMO), Poloxamer 407 (P 407) and Tween 80 (T 80) were used to formulate GS-loaded cubosomes (GS-CBS) utilizing a melt dispersion-emulsificati...

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Autors principals:	Essam M. Eissa, Mohammed H. Elkomy, Hussein M. Eid, Adel A. Ali, Mohammed A. S. Abourehab, Amal M. Alsubaiyel, Ibrahim A. Naguib, Izzeddin Alsalahat, Amira H. Hassan
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2022-06-01
Col·lecció:	Pharmaceutics
Matèries:	granisetron cubosomes in situ gel biodistribution brain targeting pharmacokinetics
Accés en línia:	https://www.mdpi.com/1999-4923/14/7/1374
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