A reliable transcriptomic risk-score applicable to formalin-fixed paraffin-embedded biopsies improves outcome prediction in localized prostate cancer

Abstract Background Clinical manifestation of prostate cancer (PCa) is highly variable. Aggressive tumors require radical treatment while clinically non-significant ones may be suitable for active surveillance. We previously developed the prognostic ProstaTrend RNA signature based on transcriptome‐w...

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Hauptverfasser:	Michael Rade, Markus Kreuz, Angelika Borkowetz, Ulrich Sommer, Conny Blumert, Susanne Füssel, Catharina Bertram, Dennis Löffler, Dominik J. Otto, Livia A. Wöller, Carolin Schimmelpfennig, Ulrike Köhl, Ann-Cathrin Gottschling, Pia Hönscheid, Gustavo B. Baretton, Manfred Wirth, Christian Thomas, Friedemann Horn, Kristin Reiche
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2024-02-01
Schriftenreihe:	Molecular Medicine
Schlagworte:	Prognostic biomarker Molecular diagnostic testing Molecular pathology Personalized medicine Prostate cancer Transcriptome
Online-Zugang:	https://doi.org/10.1186/s10020-024-00789-9
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