Apigenin Alleviates Intervertebral Disc Degeneration via Restoring Autophagy Flux in Nucleus Pulposus Cells

Oxidative stress–induced apoptosis and senescence of nucleus pulposus (NP) cells play a crucial role in the progression of intervertebral disc degeneration (IVDD). Accumulation of studies has shown that activated autophagy and enhanced autophagic flux can alleviate IVDD. In this study, we explored t...

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Detalhes bibliográficos

Principais autores:	Chenglong Xie, Yifeng Shi, Zuoxi Chen, Xin Zhou, Peng Luo, Chenxuan Hong, Naifeng Tian, Yaosen Wu, Yifei Zhou, Yan Lin, Haicheng Dou, Aimin Wu, Qishan Huang, Xiaolei Zhang, Xiangyang Wang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-01-01
coleção:	Frontiers in Cell and Developmental Biology
Assuntos:	intervertebral disc degeneration autophagy autophagic flux apoptosis senescence TFEB
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fcell.2021.787278/full
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