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Establishment of CD163-truncated gene-edited pigs and evaluation of their anti-PRRSV ability

ObjectiveThis study aims to generate Large White pigs with a five-amino acid deletion (Δ525-529, AHFGE) in the SRCR5 domain of CD163 using CRISPR/Cas9 gene editing combined with somatic cell nuclear transfer, and evaluate their resistance to porcine reproductive and respiratory syndrome virus (PRRSV...

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Principais autores: Jiayong TAN, Jian ZHANG, Xiaohui YANG, Haiwen ZHONG, Huaqiang YANG, Gengyuan CAI
Format: Artigo
Sprog:Chinês
Udgivet: South China Agricultural University 2026-05-01
Serier:Huanan Nongye Daxue xuebao
Fag:
pig
cd163-truncated
gene editing
ahfge
prrsv
antiviral breeding
Online adgang:https://journal.scau.edu.cn/article/doi/10.7671/j.issn.1001-411X.202508001
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