Optimization and kinetic modeling of interchain disulfide bond reoxidation of monoclonal antibodies in bioprocesses
Disulfide bonds play a crucial role in folding and structural stabilization of monoclonal antibodies (mAbs). Disulfide bond reduction may happen during the mAb manufacturing process, resulting in low molecular weight species and possible failure to meet product specifications. Although many mitigati...
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| Главные авторы: | , , , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Taylor & Francis Group
2020-01-01
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| Серии: | mAbs |
| Предметы: | |
| Online-ссылка: | https://www.tandfonline.com/doi/10.1080/19420862.2020.1829336 |
| Метки: |
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