Optimization and kinetic modeling of interchain disulfide bond reoxidation of monoclonal antibodies in bioprocesses

Disulfide bonds play a crucial role in folding and structural stabilization of monoclonal antibodies (mAbs). Disulfide bond reduction may happen during the mAb manufacturing process, resulting in low molecular weight species and possible failure to meet product specifications. Although many mitigati...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Peifeng Tang, Zhijun Tan, Vivekh Ehamparanathan, Tingwei Ren, Laurel Hoffman, Cheng Du, Yuanli Song, Li Tao, Angela Lewandowski, Sanchayita Ghose, Zheng Jian Li, Shijie Liu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Taylor & Francis Group 2020-01-01
Edice:	mAbs
Témata:	Monoclonal antibody disulfide bond redox/reduction/reoxidation kinetic modeling
On-line přístup:	https://www.tandfonline.com/doi/10.1080/19420862.2020.1829336
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!