Triepoxide formation by a flavin-dependent monooxygenase in monensin biosynthesis

Abstract Monensin A is a prototypical natural polyether polyketide antibiotic. It acts by binding a metal cation and facilitating its transport across the cell membrane. Biosynthesis of monensin A involves construction of a polyene polyketide backbone, subsequent epoxidation of the alkenes, and, las...

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Detalhes bibliográficos

Principais autores:	Qian Wang, Ning Liu, Yaming Deng, Yuze Guan, Hongli Xiao, Tara A. Nitka, Hui Yang, Anju Yadav, Lela Vukovic, Irimpan I. Mathews, Xi Chen, Chu-Young Kim
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2023-10-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-023-41889-0
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