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TET proteins regulate T cell and iNKT cell lineage specification in a TET2 catalytic dependent manner

TET proteins mediate DNA demethylation by oxidizing 5-methylcytosine to 5-hydroxymethylcytosine (5hmC) and other oxidative derivatives. We have previously demonstrated a dynamic enrichment of 5hmC during T and invariant natural killer T cell lineage specification. Here, we investigate shared signatu...

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Main Authors: Tarmo Äijö, Dimitris Theofilatos, Meng Cheng, Matthew D. Smith, Yue Xiong, Albert S. Baldwin, Ageliki Tsagaratou
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
TET proteins
Th-POK
DNA Methylation
5hmC
lineage specification
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.940995/full
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