SPINK2 silencing suppresses leukemic proliferation and restores myeloid commitment via MECOM downregulation in acute myeloid leukaemia

Abstract Myeloid leukaemias harboring complex karyotypes present several unrelated cytogenetic abnormalities and form a distinct subset of AML linked to a dismal prognosis. Currently, no effective options are available for the treatment of those patients, and the discovery of novel therapeutic strat...

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Prif Awduron:	Antonio Benedetto Ventura, Tiziana Loconte, Amer Ahmed, Lucia Deligio, Antonio Negri, Gabriella D’Angelo, Daria Di Molfetta, Pierre Cauchy, Barbara Mandriani, Xiao Zhang, Crescenza Pasciolla, Antonello Rana, Angela Iacobazzi, Giacomo Loseto, Mauro Cives, Luigi Viggiano, Francesco Massimo Lasorsa, Attilio Guarini, Maria Carmela Vegliante, Sabino Ciavarella, Giancarlo Castellano, Giuseppe Fiermonte, Giacomo Volpe
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Nature Publishing Group 2026-03-01
Cyfres:	Cell Death Discovery
Mynediad Ar-lein:	https://doi.org/10.1038/s41420-026-02988-1
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