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MAFB regulates hematopoietic stem cell proliferation and maintenance

Abstract MAFB, a transcription factor of the large Maf family, is expressed in both fetal liver (FL) and bone marrow (BM) hematopoietic stem cells (HSCs). However, its stage-specific roles remain elusive. Here, we reveal that MAFB plays distinct roles in FL and BM HSCs. Using Mafb-deficient and Mafb...

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Principais autores: Saki Asano, Ching-Wei Liao, Yurina Matsunaga, Hyojung Jeon, Kyoko Sawaguchi, Keigo Asano, Manabu Kusakabe, Zeynab Javanfekr Shahri, Natalia Gogoleva, Tomomasa Yokomizo, Satoru Takahashi, Michito Hamada
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2025-11-01
Serier:Scientific Reports
Fag:
MAFB
Hematopoietic stem cells (HSCs)
Self-renewal
Cell cycle regulation
Stem cell exhaustion
Online adgang:https://doi.org/10.1038/s41598-025-24389-7
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