β-hydroxybutyrate recapitulates the beneficial effects of ketogenic metabolic therapy in polycystic kidney disease

Summary: Autosomal-dominant polycystic kidney disease (ADPKD) is a common monogenic disease characterized by the formation of fluid-filled renal cysts, loss of mitochondrial function, decreased fatty acid oxidation, increased glycolysis, and likely renal failure. We previously demonstrated that indu...

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Autors principals:	Jacob A. Torres, Nickolas Holznecht, David A. Asplund, Bradley C. Kroes, Tselmeg Amarlkhagva, Matthias M. Haeffner, Elizabeth H. Sharpe, Stella Koestner, Sebastian Strubl, Margaret F. Schimmel, Samantha Kruger, Shagun Agrawal, Brina A. Aceves, Muthusamy Thangaraju, Thomas Weimbs
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2024-09-01
Col·lecció:	iScience
Matèries:	Therapy Pathophysiology Diet
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2589004224019989
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