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β-hydroxybutyrate recapitulates the beneficial effects of ketogenic metabolic therapy in polycystic kidney disease

Summary: Autosomal-dominant polycystic kidney disease (ADPKD) is a common monogenic disease characterized by the formation of fluid-filled renal cysts, loss of mitochondrial function, decreased fatty acid oxidation, increased glycolysis, and likely renal failure. We previously demonstrated that indu...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Jacob A. Torres, Nickolas Holznecht, David A. Asplund, Bradley C. Kroes, Tselmeg Amarlkhagva, Matthias M. Haeffner, Elizabeth H. Sharpe, Stella Koestner, Sebastian Strubl, Margaret F. Schimmel, Samantha Kruger, Shagun Agrawal, Brina A. Aceves, Muthusamy Thangaraju, Thomas Weimbs
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2024-09-01
Schriftenreihe:iScience
Schlagworte:
Therapy
Pathophysiology
Diet
Online-Zugang:http://www.sciencedirect.com/science/article/pii/S2589004224019989
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