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Atypical calcium regulation of the PKD2-L1 polycystin ion channel

Native PKD2-L1 channel subunits are present in primary cilia and other restricted cellular spaces. Here we investigate the mechanism for the channel's unusual regulation by external calcium, and rationalize this behavior to its specialized function. We report that the human PKD2-L1 selectivity filte...

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Bibliografiske detaljer
Principais autores: Paul G DeCaen, Xiaowen Liu, Sunday Abiria, David E Clapham
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2016-06-01
Serier:eLife
Fag:
Online adgang:https://elifesciences.org/articles/13413
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