Synthesis, Antimalarial, Antileishmanial, and Cytotoxicity Activities and Preliminary In Silico ADMET Studies of 2-(7-Chloroquinolin-4-ylamino)ethyl Benzoate Derivatives

A series of heterocyclic chloroquine hybrids, containing a chain of two carbon atoms at position four of the quinolinic chain and acting as a link between quinoline and several benzoyl groups, is synthesized and screened in vitro as an inhibitor of β-hematin formation and in vivo for its antimalaria...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Joyce E. Gutiérrez, Hegira Ramírez, Esteban Fernandez-Moreira, María E. Acosta, Michael R. Mijares, Juan Bautista De Sanctis, Soňa Gurská, Petr Džubák, Marián Hajdúch, Liesangerli Labrador-Fagúndez, Bruno G. Stella, Luis José Díaz-Pérez, Gustavo Benaim, Jaime E. Charris
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2023-12-01
Colecção:	Pharmaceuticals
Assuntos:	malaria leishmaniasis cytotoxicity ADMET chloroquine aminoalkylbenzoates
Acesso em linha:	https://www.mdpi.com/1424-8247/16/12/1709
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!