Synthesis, Antimalarial, Antileishmanial, and Cytotoxicity Activities and Preliminary In Silico ADMET Studies of 2-(7-Chloroquinolin-4-ylamino)ethyl Benzoate Derivatives

A series of heterocyclic chloroquine hybrids, containing a chain of two carbon atoms at position four of the quinolinic chain and acting as a link between quinoline and several benzoyl groups, is synthesized and screened in vitro as an inhibitor of β-hematin formation and in vivo for its antimalaria...

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主要な著者:	Joyce E. Gutiérrez, Hegira Ramírez, Esteban Fernandez-Moreira, María E. Acosta, Michael R. Mijares, Juan Bautista De Sanctis, Soňa Gurská, Petr Džubák, Marián Hajdúch, Liesangerli Labrador-Fagúndez, Bruno G. Stella, Luis José Díaz-Pérez, Gustavo Benaim, Jaime E. Charris
フォーマット:	Artigo
言語:	Inglês
出版事項:	MDPI AG 2023-12-01
シリーズ:	Pharmaceuticals
主題:	malaria leishmaniasis cytotoxicity ADMET chloroquine aminoalkylbenzoates
オンライン･アクセス:	https://www.mdpi.com/1424-8247/16/12/1709
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