Nanobody-mediated macromolecular crowding induces membrane fission and remodeling in the African trypanosome

Summary: The dense variant surface glycoprotein (VSG) coat of African trypanosomes represents the primary host-pathogen interface. Antigenic variation prevents clearing of the pathogen by employing a large repertoire of antigenically distinct VSG genes, thus neutralizing the host’s antibody response...

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Detalhes bibliográficos

Principais autores:	Alexander Hempelmann, Laura Hartleb, Monique van Straaten, Hamidreza Hashemi, Johan P. Zeelen, Kevin Bongers, F. Nina Papavasiliou, Markus Engstler, C. Erec Stebbins, Nicola G. Jones
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2021-11-01
coleção:	Cell Reports
Assuntos:	African trypanosome host-pathogen interaction variant surface glycoproteins immune epitope mapping structural biology nanovesicle formation
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2211124721013966
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