FLT3-SYK inhibitor and Ixazomib combination impact HOXA and oxidative stress control by β-catenin, SQSTM1 and NRF2 in AML

Abstract Acute myeloid leukemia (AML) is sustained by oncogenic signaling and stress-adaptive networks that enable proliferative sustenance and therapeutic resistance. Transcriptomic profiling of AML blasts revealed upregulation of FLT3, SYK, HOXA9/10, and CTNNB1 with elevated oxidative phosphorylat...

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Bibliografiske detaljer

Principais autores:	Santhosh Kumar Pasupuleti, Sravanti Rangaraju, Justin Layer, Kanaka Sai Ram Padam, Larry D. Cripe, Hamid Sayar, Katie J. Sargent, Jill Weisenbach, Heiko Konig, Huda Salman, Baskar Ramdas, Lakshmi Reddy Palam, Lindsey D. Mayo, Irum Khan, Utpal P. Davé, H. Scott Boswell, Reuben Kapur
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2026-02-01
Serier:	npj Precision Oncology
Online adgang:	https://doi.org/10.1038/s41698-026-01332-1
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