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Advances, challenges, and opportunities of human midbrain organoids for modelling of the dopaminergic system

Abstract Dopaminergic neurons in the ventral midbrain are critical for regulating movement, cognition, and emotion. Ventral midbrain organoids can be used to model both development and diseases of the dopaminergic system, especially Parkinson’s disease. Here, we summarize recent advances and remaini...

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Huvudupphov: Alessandro Fiorenzano, Edoardo Sozzi, Rahel Kastli, Maria Roberta Iazzetta, Andreas Bruzelius, Paola Arlotta, Malin Parmar
Materialtyp: Artigo
Språk:Inglês
Utgiven: Springer Nature 2025-07-01
Serie:The EMBO Journal
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Länkar:https://doi.org/10.1038/s44318-025-00494-1
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