In vitro derivation of midbrain dopaminergic neurons from porcine embryonic stem cells in multi-dimensional conditions

Abstract Background . Porcine pluripotent stem cells hold significant promise as a large-animal model for human neurodevelopment and disease modeling. However, efficient protocols for their directed differentiation into midbrain dopaminergic (mDA) neurons and the generation of 3D midbrain-like organ...

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Hauptverfasser: Hyerin Choi, Dongjin Oh, Ali Jawad, Zheng Haomiao, Jaehyung Ham, Juyoung Heo, Aram Oh, Huijin Jin, Jaehyeok Seo, Byoung Chol Oh, Sang-Hwan Hyun
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2025-11-01
Schriftenreihe:Stem Cell Research & Therapy
Schlagworte:
Porcine
Embryonic stem cells
Midbrain
Dopaminergic neuron
Organoid
Online Zugang:https://doi.org/10.1186/s13287-025-04693-9
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