QR Code

Pharmaceuticals Promoting Premature Termination Codon Readthrough: Progress in Development

Around 11% of all known gene lesions causing human genetic diseases are nonsense mutations that introduce a premature stop codon (PTC) into the protein-coding gene sequence. Drug-induced PTC readthrough is a promising therapeutic strategy for treating hereditary diseases caused by nonsense mutations...

Full description

Saved in:
Main Authors: Shan Li, Juan Li, Wenjing Shi, Ziyan Nie, Shasha Zhang, Fengdie Ma, Jun Hu, Jianjun Chen, Peiqiang Li, Xiaodong Xie
Format: Artigo
Language:Inglês
Published: MDPI AG 2023-06-01
Series:Biomolecules
Subjects:
nonsense mutation
premature termination codon (PTC)
translational readthrough-inducing drugs (TRIDs)
nonsense suppression
readthrough therapy
Online Access:https://www.mdpi.com/2218-273X/13/6/988
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items