Pharmaceuticals Promoting Premature Termination Codon Readthrough: Progress in Development

Around 11% of all known gene lesions causing human genetic diseases are nonsense mutations that introduce a premature stop codon (PTC) into the protein-coding gene sequence. Drug-induced PTC readthrough is a promising therapeutic strategy for treating hereditary diseases caused by nonsense mutations...

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Autors principals:	Shan Li, Juan Li, Wenjing Shi, Ziyan Nie, Shasha Zhang, Fengdie Ma, Jun Hu, Jianjun Chen, Peiqiang Li, Xiaodong Xie
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2023-06-01
Col·lecció:	Biomolecules
Matèries:	nonsense mutation premature termination codon (PTC) translational readthrough-inducing drugs (TRIDs) nonsense suppression readthrough therapy
Accés en línia:	https://www.mdpi.com/2218-273X/13/6/988
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