Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase

Inorganic anions inhibit the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) generally by coordinating to the active site metal ion. Cyanate was reported as a non-coordinating CA inhibitor but those erroneous results were subsequently corrected by another group. We review the anion CA inhibitors (...

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Hlavní autoři:	Alessio Nocentini, Andrea Angeli, Fabrizio Carta, Jean-Yves Winum, Raivis Zalubovskis, Simone Carradori, Clemente Capasso, William A. Donald, Claudiu T. Supuran
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Taylor & Francis Group 2021-01-01
Edice:	Journal of Enzyme Inhibition and Medicinal Chemistry
Témata:	carbonic anhydrase inhibitor sulphonamide inhibition mechanisms cyanate
On-line přístup:	http://dx.doi.org/10.1080/14756366.2021.1882453
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