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Antiproliferative effects of sulphonamide carbonic anhydrase inhibitors C18, SLC-0111 and acetazolamide on bladder, glioblastoma and pancreatic cancer cell lines

Carbonic anhydrase IX/XII (CA IX/XII), are cell-surface enzymes typically expressed by cancer cells as a form of adaptation to hypoxia and acidosis. It has been widely reported that these proteins play pivotal roles in cancer progression fostering cell migration, aggressiveness and resistance to fir...

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Principais autores: Silvia Mussi, Sara Rezzola, Paola Chiodelli, Alessio Nocentini, Claudiu T. Supuran, Roberto Ronca
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis Group 2022-01-01
Serier:Journal of Enzyme Inhibition and Medicinal Chemistry
Fag:
carbonic anhydrase inhibitors
glioblastoma
bladder cancer
pancreatic cancer
slc-0111
Online adgang:http://dx.doi.org/10.1080/14756366.2021.2004592
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