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CRIPTO antagonist ALK4L75A-Fc inhibits breast cancer cell plasticity and adaptation to stress

Abstract Background CRIPTO is a multi-functional signaling protein that promotes stemness and oncogenesis. We previously developed a CRIPTO antagonist, ALK4L75A-Fc, and showed that it causes loss of the stem cell phenotype in normal mammary epithelia suggesting it may similarly inhibit CRIPTO-depend...

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Autori principali: Ozlen Balcioglu, Richard E. Heinz, David W. Freeman, Brooke L. Gates, Berhane M. Hagos, Evan Booker, Elnaz Mirzaei Mehrabad, Hyrum T. Diesen, Kishan Bhakta, Supraja Ranganathan, Masami Kachi, Mathias Leblanc, Peter C. Gray, Benjamin T. Spike
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2020-11-01
Serie:Breast Cancer Research
Soggetti:
Breast cancer
Plasticity
CRIPTO
Stress adaptation
Cancer stem cells
Accesso online:http://link.springer.com/article/10.1186/s13058-020-01361-z
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