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CRIPTO antagonist ALK4L75A-Fc inhibits breast cancer cell plasticity and adaptation to stress

Abstract Background CRIPTO is a multi-functional signaling protein that promotes stemness and oncogenesis. We previously developed a CRIPTO antagonist, ALK4L75A-Fc, and showed that it causes loss of the stem cell phenotype in normal mammary epithelia suggesting it may similarly inhibit CRIPTO-depend...

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Principais autores: Ozlen Balcioglu, Richard E. Heinz, David W. Freeman, Brooke L. Gates, Berhane M. Hagos, Evan Booker, Elnaz Mirzaei Mehrabad, Hyrum T. Diesen, Kishan Bhakta, Supraja Ranganathan, Masami Kachi, Mathias Leblanc, Peter C. Gray, Benjamin T. Spike
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2020-11-01
coleção:Breast Cancer Research
Assuntos:
Breast cancer
Plasticity
CRIPTO
Stress adaptation
Cancer stem cells
Acesso em linha:http://link.springer.com/article/10.1186/s13058-020-01361-z
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