A protective trend of N-acetylcysteine against aluminum-induced hepatotoxicity in rats involving the Nrf2/HO-1 and NF-κB pathways

Aluminum (Al), the most abundant metal in the Earth's crust, can enter organisms through multiple pathways, and its accumulation has been confirmed to induce hepatic injury. As an antioxidant, N-acetylcysteine (NAC) has been validated for decades for its ability to counteract oxidative stress; howev...

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Principais autores:	Xi Wei, Yingchuan Wang, Siling Huang, ErBing Lin, Yidi Xu, Liufang Zhou
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2026-08-01
Colecção:	Ecotoxicology and Environmental Safety
Assuntos:	Aluminum N-acetylcysteine Nrf2/HO-1 pathway NF-κB pathway Apoptosis
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S0147651326007633
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