Prickle1 mutation causes planar cell polarity and directional cell migration defects associated with cardiac outflow tract anomalies and other structural birth defects

Planar cell polarity (PCP) is controlled by a conserved pathway that regulates directional cell behavior. Here, we show that mutant mice harboring a newly described mutation termed Beetlejuice (Bj) in Prickle1 (Pk1), a PCP component, exhibit developmental phenotypes involving cell polarity defects,...

وصف كامل

التفاصيل البيبلوغرافية

المؤلفون الرئيسيون:	Brian C. Gibbs, Rama Rao Damerla, Eszter K. Vladar, Bishwanath Chatterjee, Yong Wan, Xiaoqin Liu, Cheng Cui, George C. Gabriel, Maliha Zahid, Hisato Yagi, Heather L. Szabo-Rogers, Kaye L. Suyama, Jeffrey D. Axelrod, Cecilia W. Lo
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	The Company of Biologists 2016-03-01
سلاسل:	Biology Open
الموضوعات:	Biliary atresia Cell polarity Outflow tract Prickle1
الوصول للمادة أونلاين:	http://bio.biologists.org/content/5/3/323
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!