Prickle1 mutation causes planar cell polarity and directional cell migration defects associated with cardiac outflow tract anomalies and other structural birth defects

Planar cell polarity (PCP) is controlled by a conserved pathway that regulates directional cell behavior. Here, we show that mutant mice harboring a newly described mutation termed Beetlejuice (Bj) in Prickle1 (Pk1), a PCP component, exhibit developmental phenotypes involving cell polarity defects,...

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Autors principals:	Brian C. Gibbs, Rama Rao Damerla, Eszter K. Vladar, Bishwanath Chatterjee, Yong Wan, Xiaoqin Liu, Cheng Cui, George C. Gabriel, Maliha Zahid, Hisato Yagi, Heather L. Szabo-Rogers, Kaye L. Suyama, Jeffrey D. Axelrod, Cecilia W. Lo
Format:	Artigo
Idioma:	Inglês
Publicat:	The Company of Biologists 2016-03-01
Col·lecció:	Biology Open
Matèries:	Biliary atresia Cell polarity Outflow tract Prickle1
Accés en línia:	http://bio.biologists.org/content/5/3/323
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