NF-κB inhibition in keratinocytes causes RIPK1-mediated necroptosis and skin inflammation
TNFR1 was found to cause skin inflammation in mice with epidermal keratinocyte-specific ablation of IKK2 or of both the NF-kB subunits RelA and cRel by triggering RIPK1-dependent, RIPK3-MLKL–mediated necroptosis of keratinocytes. Tumor necrosis factor receptor 1 (TNFR1) activates NF-κB–dependent pro...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
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Life Science Alliance LLC
2021-06-01
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| Schriftenreihe: | Life Science Alliance |
| Online-Zugang: | https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.202000956 |
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