Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis

Linear Ubiquitin chain Assembly Complex (LUBAC) is an E3 ligase complex that generates linear ubiquitin chains and is important for tumour necrosis factor (TNF) signaling activation. Mice lacking Sharpin, a critical subunit of LUBAC, spontaneously develop inflammatory lesions in the skin and other o...

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Principais autores:	Snehlata Kumari, Younes Redouane, Jaime Lopez-Mosqueda, Ryoko Shiraishi, Malgorzata Romanowska, Stefan Lutzmayer, Jan Kuiper, Conception Martinez, Ivan Dikic, Manolis Pasparakis, Fumiyo Ikeda
格式:	Artigo
語言:	Inglês
出版:	eLife Sciences Publications Ltd 2014-12-01
叢編:	eLife
主題:	ubiquitin TNFR1 Sharpin skin inflammation apoptosis LUBAC
在線閱讀:	https://elifesciences.org/articles/03422
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