Single‐cell and spatial analyses reveal the association between gene expression of glutamine synthetase with the immunosuppressive phenotype of APOE+CTSZ+TAM in cancers

An immunosuppressive state is regulated by various factors in the tumor microenvironment (TME), including, but not limited to, metabolic plasticity of immunosuppressive cells and cytokines secreted by these cells. We used single‐cell RNA‐sequencing (scRNA‐seq) data and applied single‐cell flux estim...

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Autors principals:	Jinfen Wei, Wenqi Yu, Juanzhi Chen, Guanda Huang, Lingjie Zhang, Zixi Chen, Meiling Hu, Xiaocheng Gong, Hongli Du
Format:	Artigo
Idioma:	Inglês
Publicat:	Wiley 2023-04-01
Col·lecció:	Molecular Oncology
Matèries:	colorectal cancer GLUL immunosuppressive microenvironment metabolism single‐cell and spatial RNA‐seq tumor‐associated macrophages
Accés en línia:	https://doi.org/10.1002/1878-0261.13373
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