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Age-related skeletal dynamics and decrease in bone strength in DNA repair deficient male trichothiodystrophy mice.

Accumulation of DNA damage caused by oxidative stress is thought to be one of the main contributors of human tissue aging. Trichothiodystrophy (TTD) mice have a mutation in the Ercc2 DNA repair gene, resulting in accumulation of DNA damage and several features of segmental accelerated aging. We used...

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Principais autores: Claudia Nicolaije, Karin E M Diderich, S M Botter, Matthias Priemel, Jan H Waarsing, Judd S Day, Renata M C Brandt, Arndt F Schilling, Harrie Weinans, Bram C Van der Eerden, Gijsbertus T J van der Horst, Jan H J Hoeijmakers, Johannes P T M van Leeuwen
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2012-01-01
coleção:PLoS ONE
Acesso em linha:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0035246&type=printable
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