Adaptive stress response in segmental progeria resembles long-lived dwarfism and calorie restriction in mice.

How congenital defects causing genome instability can result in the pleiotropic symptoms reminiscent of aging but in a segmental and accelerated fashion remains largely unknown. Most segmental progerias are associated with accelerated fibroblast senescence, suggesting that cellular senescence is a l...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Marieke van de Ven, Jaan-Olle Andressoo, Valerie B Holcomb, Marieke von Lindern, Willeke M C Jong, Chris I De Zeeuw, Yousin Suh, Paul Hasty, Jan H J Hoeijmakers, Gijsbertus T J van der Horst, James R Mitchell
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2006-12-01
coleção:	PLoS Genetics
Acesso em linha:	http://europepmc.org/articles/PMC1698946?pdf=render
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!