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The exceptions that prove the rule—a historical view of bedaquiline susceptibility

Abstract In the accompanying study, Nimmo and colleagues estimated the dates of emergence of mutations in mmpR5 (Rv0678), the most important resistance gene to the anti-tuberculosis drug bedaquiline, in over 3500 geographically diverse Mycobacterium tuberculosis genomes. This provided important insi...

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Principais autores: Paolo Miotto, Daniela M. Cirillo, Thomas Schön, Claudio U. Köser
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-03-01
Serier:Genome Medicine
Fag:
Mycobacterium tuberculosis
Bedaquiline susceptibility
Resistance mutations
Clinical trials
Online adgang:https://doi.org/10.1186/s13073-024-01311-w
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