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Mechanism of interaction between TTR tetramer and Aβ42 oligomers: Dependence on the Aβ42 oligomeric size and morphology

β-amyloid (Aβ) deposits are the leading cause of Alzheimer's disease. Many studies have confirmed that transthyretin (TTR) inhibits the cytotoxicity of Aβ oligomers (AβOs) with various species (oligomers and protofibrils, but not monomers) through their interactions. Here, we investigated the mechan...

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Principais autores: Jinfei Mei, Wenqi Gao, Yvning Guan, Sajjad Ahmad, Fahad Nouman Muhammad, Hongqi Ai
Format: Artigo
Sprog:Inglês
Udgivet: KeAi Communications Co., Ltd. 2025-04-01
Serier:ChemPhysMater
Fag:
Transthyretin
Aβ oligomer
Mechanism of interaction
Molecular weight
Dependence
Online adgang:http://www.sciencedirect.com/science/article/pii/S2772571525000099
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