Mechanism of interaction between TTR tetramer and Aβ42 oligomers: Dependence on the Aβ42 oligomeric size and morphology

β-amyloid (Aβ) deposits are the leading cause of Alzheimer's disease. Many studies have confirmed that transthyretin (TTR) inhibits the cytotoxicity of Aβ oligomers (AβOs) with various species (oligomers and protofibrils, but not monomers) through their interactions. Here, we investigated the mechan...

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Autores principales:	Jinfei Mei, Wenqi Gao, Yvning Guan, Sajjad Ahmad, Fahad Nouman Muhammad, Hongqi Ai
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	KeAi Communications Co., Ltd. 2025-04-01
Colección:	ChemPhysMater
Materias:	Transthyretin Aβ oligomer Mechanism of interaction Molecular weight Dependence
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S2772571525000099
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