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Machine learning approaches to detect hepatocyte chromatin alterations from iron oxide nanoparticle exposure

Abstract This study focuses on developing machine learning models to detect subtle alterations in hepatocyte chromatin organization due to Iron (II, III) oxide nanoparticle exposure, hypothesizing that exposure will significantly alter chromatin texture. A total of 2000 hepatocyte nuclear regions of...

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Principais autores: Jovana Paunovic Pantic, Danijela Vucevic, Tatjana Radosavljevic, Peter R. Corridon, Svetlana Valjarevic, Jelena Cumic, Ljubisa Bojic, Igor Pantic
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2024-08-01
Serier:Scientific Reports
Fag:
Machine learning
Nucleus
Random forest
Gradient boosting
Toxicology
Online adgang:https://doi.org/10.1038/s41598-024-70559-4
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