Impacts of APOE-ε4 and exercise training on brain microvascular endothelial cell barrier function and metabolismResearch in context

Summary: Background: The APOE-ε4 genotype is the highest genetic risk factor for Alzheimer's disease (AD), and exercise training can reduce the risk of AD. Two early pathologies of AD are degradation of tight junctions between brain microvascular endothelial cells (BMEC) and brain glucose hypometab...

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Principais autores:	Callie M. Weber, Bilal Moiz, Gabriel S. Pena, Marzyeh Kheradmand, Brooke Wunderler, Claire Kettula, Gurneet S. Sangha, J. Carson Smith, Alisa Morss Clyne
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2025-01-01
Colecção:	EBioMedicine
Assuntos:	Blood-brain barrier Alzheimer's disease Glucose metabolism APOE genotype Exercise training
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2352396424005231
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