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ICOS+ T helper 2 cells promote the pulmonary fibrosis in systemic sclerosis

Abstract Background Interstitial lung disease (ILD) is the most frequent complication of systemic sclerosis (SSc), associated with a poor prognosis and limited treatments. T helper 2 (Th2) cells play a key role in SSc pathogenesis, with T cell inducible co-stimulator (ICOS) involved in Th2 different...

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Hauptverfasser: Huimin Zhu, Yuxuan Chen, Yingyi Wu, Yue Zhang, Shanshan Liu, Na You, Mian Liu, Zhikang Wang, Dandan Wang, Lingyun Sun
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2026-03-01
Schriftenreihe:Molecular Medicine
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Online-Zugang:https://doi.org/10.1186/s10020-026-01455-y
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