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Iloprost Attenuates Oxidative Stress-Dependent Activation of Collagen Synthesis Induced by Sera from Scleroderma Patients in Human Pulmonary Microvascular Endothelial Cells

Endothelial cell injury is an early event in systemic sclerosis (SSc) pathogenesis and several studies indicate oxidative stress as the trigger of SSc-associated vasculopathy. Here, we show that circulating factors present in sera of SSc patients increased reactive oxygen species (ROS) production an...

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Hlavní autoři: Roberta Giordo, Duong Thi Bich Thuan, Anna Maria Posadino, Annalisa Cossu, Angelo Zinellu, Gian Luca Erre, Gianfranco Pintus
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI AG 2021-08-01
Edice:Molecules
Témata:
systemic sclerosis
oxidative stress
collagen synthesis
iloprost
On-line přístup:https://www.mdpi.com/1420-3049/26/16/4729
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