UPR in palmitate-treated pancreatic beta-cells is not affected by altering oxidation of the fatty acid

<p>Abstract</p> <p>Background</p> <p>Elevated levels of lipids are detrimental for beta-cell function and mass. One of the mechanisms of how fatty acids induce apoptosis is development of the unfolded protein response (UPR). It is still far from understood how fatty acids activate the UPR, however.<...

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Hlavní autoři:	Sol E-ri, Sargsyan Ernest, Bergsten Peter
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2011-10-01
Edice:	Nutrition & Metabolism
Témata:	beta-cell human islets palmitate oxidation ER stress unfolded protein response
On-line přístup:	http://www.nutritionandmetabolism.com/content/8/1/70
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