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Protective effect of empagliflozin against palmitate-induced lipotoxicity through AMPK in H9c2 cells

Sodium-glucose cotransporter 2 (SGLT2) inhibitors have recently emerged as novel cardioprotective agents. However, their direct impact on cardiomyocyte injury is yet to be studied. In this work, we investigate the underlying molecular mechanisms of empagliflozin (EMPA), an SGLT2 inhibitor, in mitiga...

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Principais autores: Min-Woo Song, Wenhao Cui, Chang-Gun Lee, Rihua Cui, Young Ho Son, Young Ha Kim, Yujin Kim, Hae Jin Kim, Sung-E. Choi, Yup Kang, Tae Ho Kim, Ja Young Jeon, Kwan-Woo Lee
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2023-12-01
Serier:Frontiers in Pharmacology
Fag:
EMPA
palmitate
cardiomyocyte
AMPK
SGLT2 inhibitor
lipotoxicity
Online adgang:https://www.frontiersin.org/articles/10.3389/fphar.2023.1228646/full
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