Tn Antigen Expression Contributes to an Immune Suppressive Microenvironment and Drives Tumor Growth in Colorectal Cancer

Expression of the tumor-associated glycan Tn antigen (αGalNAc-Ser/Thr) has been correlated to poor prognosis and metastasis in multiple cancer types. However, the exact mechanisms exerted by Tn antigen to support tumor growth are still lacking. One emerging hallmark of cancer is evasion of immune de...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Lenneke A. M. Cornelissen, Athanasios Blanas, Anouk Zaal, Joost C. van der Horst, Laura J. W. Kruijssen, Tom O’Toole, Yvette van Kooyk, Sandra J. van Vliet
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2020-08-01
Schriftenreihe:	Frontiers in Oncology
Schlagworte:	colorectal cancer O-glycosylation Tn antigen anti-tumor immunity tumor growth
Online-Zugang:	https://www.frontiersin.org/article/10.3389/fonc.2020.01622/full
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!