Binding pocket stabilization by high-throughput screening of yeast display libraries

Protein dynamics have a great influence on the binding pockets of some therapeutic targets. Flexible protein binding sites can result in transient binding pocket formation which might have a negative impact on drug screening efforts. Here, we describe a protein engineering strategy with FK506-bindin...

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التفاصيل البيبلوغرافية

المؤلفون الرئيسيون:	Jorge A. Lerma Romero, Christian Meyners, Andreas Christmann, Lisa M. Reinbold, Anna Charalampidou, Felix Hausch, Harald Kolmar
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	Frontiers Media S.A. 2022-11-01
سلاسل:	Frontiers in Molecular Biosciences
الموضوعات:	protein engineering transient binding pocket yeast display flow cytometry FKBP high-throughput screening
الوصول للمادة أونلاين:	https://www.frontiersin.org/articles/10.3389/fmolb.2022.1023131/full
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!