Binding pocket stabilization by high-throughput screening of yeast display libraries

Protein dynamics have a great influence on the binding pockets of some therapeutic targets. Flexible protein binding sites can result in transient binding pocket formation which might have a negative impact on drug screening efforts. Here, we describe a protein engineering strategy with FK506-bindin...

Fuld beskrivelse

Bibliografiske detaljer

Principais autores:	Jorge A. Lerma Romero, Christian Meyners, Andreas Christmann, Lisa M. Reinbold, Anna Charalampidou, Felix Hausch, Harald Kolmar
Format:	Artigo
Sprog:	Inglês
Udgivet:	Frontiers Media S.A. 2022-11-01
Serier:	Frontiers in Molecular Biosciences
Fag:	protein engineering transient binding pocket yeast display flow cytometry FKBP high-throughput screening
Online adgang:	https://www.frontiersin.org/articles/10.3389/fmolb.2022.1023131/full
Tags:	Tilføj Tag Ingen Tags, Vær først til at tagge denne postø!