Multi-omic approach identifies hypoxic tumor-associated myeloid cells that drive immunobiology of high-risk pediatric ependymoma

Summary: Ependymoma (EPN) is a devastating childhood brain tumor. Single-cell analyses have illustrated the cellular heterogeneity of EPN tumors, identifying multiple neoplastic cell states including a mesenchymal-differentiated subpopulation which characterizes the PFA1 subtype. Here, we characteri...

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Detalhes bibliográficos

Principais autores:	Andrea M. Griesinger, Kent Riemondy, Nithyashri Eswaran, Andrew M. Donson, Nicholas Willard, Eric W. Prince, Simon M.L. Paine, Georgia Bowes, John Rheaume, Rebecca J. Chapman, Judith Ramage, Andrew Jackson, Richard G. Grundy, Nicholas K. Foreman, Timothy A. Ritzmann
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2023-09-01
Colecção:	iScience
Assuntos:	Microenvironment Biopsy sample Components of the immune system Proteomics Transcriptomics
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2589004223016620
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